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--- public:loadedtestcases:tc15 [2012/12/06 21:34] – andreas
+++ public:loadedtestcases:tc15 [2019/02/12 09:04] (current) – external edit 127.0.0.1
@@ Line 36: / Line 36: @@
 International Sheep Genomics Consortium (http://www.sheephapmap.org)
 ==Initial state of the Test case==
-)RNA sequencing and micro-RNA profiling (Illumina HiSeq2000); approximately 18 individuals in 2013
+  - RNA sequencing and micro-RNA profiling (Illumina HiSeq2000); approximately 18 individuals in 2013
-)Whole-genome SNP genotyping (Illumina ovine 700K SNP BeadChip); >1,000 individuals for population genomics analysis and GWAS in 2013
+  - Whole-genome SNP genotyping (Illumina ovine 700K SNP BeadChip); >1,000 individuals for population genomics analysis and GWAS in 2013
-) Whole-genome sequences (Illumina HiSeq2000); “few individuals” selected from the feeding experiment in 2014
+  - Whole-genome sequences (Illumina HiSeq2000); “few individuals” selected from the feeding experiment in 2014
 In addition, there are available Sheep HapMap (http://www.sheephapmap.org) whole-genome sequence data. In total, 75 genomes of sheep have been sequenced (Illumina and Roche 454 approach).
@@ Line 45: / Line 45: @@
 ==Desired final state of the Test Case==
 The objectives of the SOMICS-project are:
-) By applying genome-wide association studies, we aim to identify the SNP variations and the candidate genes associated with different fertility phenotypes of sheep and to detect signatures of selective sweeps.
+  - By applying genome-wide association studies, we aim to identify the SNP variations and the candidate genes associated with different fertility phenotypes of sheep and to detect signatures of selective sweeps.
-) By further sequencing candidate regions and whole-genome sequencing of few sheep samples with different phenotypes, we aim to get a detailed and whole picture of functionally relevant candidate regions and the whole genomic profile of few sheep.
+  - By further sequencing candidate regions and whole-genome sequencing of few sheep samples with different phenotypes, we aim to get a detailed and whole picture of functionally relevant candidate regions and the whole genomic profile of few sheep.
-) By using the statistical and bioinformatics methods in conducting the global analyses of the multiple data sets including the molecular, nutritional and environmental data for the sheep breeds, we aim to uncover accurate gene interaction networks and pathways. We further compare the genomics of sheep with other mammals such as mice and human.
+  - By using the statistical and bioinformatics methods in conducting the global analyses of the multiple data sets including the molecular, nutritional and environmental data for the sheep breeds, we aim to uncover accurate gene interaction networks and pathways. We further compare the genomics of sheep with other mammals such as mice and human.
-) By designing a feeding experiment for diffrent sheep breeds and by investigating transcriptome and micro-RNA sequences of the breeds, we aim to evaluate the effect of nutrition on gene expression patterns and to infer putative candidate genes for the prolificacy of sheep.
+  - By designing a feeding experiment for diffrent sheep breeds and by investigating transcriptome and micro-RNA sequences of the breeds, we aim to evaluate the effect of nutrition on gene expression patterns and to infer putative candidate genes for the prolificacy of sheep.

public/loadedtestcases/tc15.1354829651.txt.gz · Last modified: 2019/02/12 09:04 (external edit)